Motu 828mkIII is great and if it had midi control in stand-alone mode it would be heaven! RME has full midi control, obviously better sound quality, but have no built in per channel eq/filter and compressor (what was important for me) - though I understand you can use send-return strategy, if you have an external effect processor, on RME as well. Of course, all these effect things are more important for mixer and not so important to interface.
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