Okay, small update - I've tried the Virus Reset (Hold ARP Edit, wait 10 secs) and its not that, So i took the Virus to a different machine and plugged it all in - installed OS3. Virus connected up fine, ran it through Ableton 6 to check, VST and audio sends functioning fine.
So this is definately a machine issue, I'm going to bust into my PC and see what the crack is.
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