I'm using Motu Traveler with Windows XP (Intel Core2 quad), and it works great. Regularly running audio from external synths/guitar into the computer and using VST effects on the incoming signal in near realtime at 1.5ms (44100Hz @ 64 buffer, or even 96000Hz @ 128 buffer) without any glitches. Admittedly I haven't stressed it with loads of multi-channel stuff, but am gearing up various things to try it.
If I'd had the money I'd have gone for the RME Fireface, but am pretty happy with the Motu. Has a nice GUI screen and routing possibilities too. Because it can be bus-powered by 6-pin firewire from the computer (which is the way I'm using it), it also removes one possibility of floating earth/ground issues too. You can still use a power adapter if you wish, though.
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PS > And another thing! Will the Ti|3 have user customisable/importable wavetables?  A ribbon-controller or XY-Pad might be nice, too, please! Thanks!
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