I must confess I don't really understand the focus on knob placement (if that's what was meant by layout) with regard to vsts. With something as wide as a hardware board, I think it can matter if one knob is a foot or two away from another, because of the physical layout of the studio. But with plugins, the knobs are never farther away from each other than a 1-2" movement of the mouse (if they are, adjust mouse senstivity), and a lot of people would just bind the VST knobs to their MIDI controller anyway so that cutoff, res, ADSR etc is in the same place for every synth.
But maybe I was misunderstanding the question?
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