Hardware is more responsive than software when you are interacting directly with the hardware itself (live on stage, in studio etc). However when you get closer to what you want to produce, I find hardware MIDI delays/latency etc to be an issue, which makes it much less responsive if thats the right word.
As far as Komplete and Reason... I'm not sure about those since I have used neither. I could name three VSTs that could all be purchased together for probably under $600 US that will solve almost any synth need, polyphony only limited by the CPU you have, no latency, there would be no upgrade cost beyond that, and you would get both PC and Mac for same price. I'm not sure the same value situation exists in the hardware synth world.
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