I'm at work so I can't listen. However, I think I know roughly what you mean. Like the massive "guitar" sound in Spitfire by The Prodigy?
If so, I have been able to create sounds like that before. If I remember right, it was using a combination of a few different techniques, including:
Unison
noise-based FM
Lots of distortion :>
Amp envelope is important to give it impact, pay particular attention to the attack and release knobs. Also remember it won't truly have an impact until you have a kick drum punching in at the start of the sound. :>
-Annikk
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