Well, I always cover my equipment with a towel, if I am smoking. I also have a duster, and dust my equipment at least once a week, if not more.
My studio is in my bedroom, so it can be hard to keep it clean... but pretty much I clean my room once a week, for the sole reason that I find it hard to concentrate when my surroundings are in disarray.
So to answer your question... just you know, do it. Clean it, and it shall be clean.
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