If your sequencer is sending MIDI clock to Virus, the tempo change affects the time-synced FX and other features of the Virus.
For example a sudden time change in synced delay FX causes a short high pitchshift in the delay. You can try it out by playing a patch with long delay and then manually reducing the delay time while playing.
Summa summarum: Switch off the MIDI clock send from the sequencer if you wish to use tempo changes.
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