I say go for the analogue mixer.
Driving channels to breaking point sounds far better than their digital counterparts for one, and currently the mixer EQs on the latest sequencers are worth a pinch of shit. Admitadly the plug in EQs are getting better, but still abusing them by boosting rather than subtracting they sound well.....horrible.
I think something depends on the type of music you're doing though. Clean and clinical vs rough and dirty.