DannyA - if you have an audio and midi interface allready, you may want to try disconnecting the USB cable from the TI for now and using it as a regular hardware synth if the problems you are experiencing arfe too frequent and/or troublesome to live with.
I use it with Cubase SX 3 on a PC and mostly it is quite well behaved.
The other conseration (that is nothing more than speculation on my part based upon having a TI for nearly 6 months) is that it seems very sensitive to the clock stabilility of your sound card.
Even when using the USB connection, unless the TI is also acting as your ASIO audio interface, then your sequencer will typically sync its tempo clock to the audio clock. If the audio clock is a little jittery, or the sequencer is not very good at deriving an absolutely rock solid stable midi (tempo) clock from the audio card, then the TI seems to get upset - crashes, screaches, arp sync issues, stuck notes etc all become far more likely.
Even synths that many would consider to be rock solid and reliable may start to make odd squeaks with unstable clocks. The instability will rarely be enough for you to notice as audiable jitters (really bad jiters may give a tiny momentary pitch change in audio), but can easily be enough to upset the TI and aggrivate underlying problems in it.
Other fixes to explore - increase audio latencies, decrease sample rate (if above 44.1K) - either can take a bit of timing stress off the application and enable it to maintain more accurate timing - which can help the TI be much more stable.
Someone suggested that if your audio card has a SPDIF input that can force the audio card to slave-sync to the TI (from its SPDIF out), then everything can get alot more stable.
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