"Virus MIDI" are the physical MIDI ports on the TI made available for use by the host computer.
"Virus Synth" are the TI hardware - outgoing to the synth engine (except when VC is running) and input from the controls and keyboard.
Typically with VC running, you use Virus Synth as input to record what you are playing as midi and ignore the rest unless you are also using it as a midi interface for your computer.
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